ĭrug Composition: Warfarin is a racemic mixture composed of R and S enantiomers of the drug. Patient-specific factors such as drug metabolism, the presence of a vitamin K enriched diet, genetics, quantity of vitamin K-dependent clotting factors, concurrent disease states, binding proteins, concomitant drug interactions, laboratory testing, and medication adherence requires assessment when dosing warfarin. The dose-response of warfarin among patients is highly variable and depends on interpatient differences. By instructing patients to take warfarin later in the day, healthcare providers can have the opportunity to individualize a patient's warfarin dose the same day based on their most current lab values. Warfarin administration can be at any time during the day, but recommendations are for administration in the afternoon or evening. Warfarin is a once-daily oral medication.
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